The second woe comes upon the earth in Revelation 9:12-21. This occurs during the time on earth known as the Tribulation. A celestial messenger of God sounds a trumpet and releases four supernatural messengers (bound today at the Euphrates River), who in turn release 200 million supernatural animals and
riders (called in Revelation 9:16, “troops of calvary”), who set out to kill a third of humanity.
The targets of this divinely-sanctioned killing are not the obvious evil-doers of earth, but rather the demon-worshipping devotees of religion who, being the dupes of Satan, have kept the true God and Christ from the consciousness of the world for two-thousand years.